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Wine and health
Harvard reveals the secrets of a better-quality life

New studies conducted by scientists from the Harvard Medical School show that the wine intake may improve health. Resveratrol would be the secret of this truth fountain of youth.


If today’s party my youth is
I shall offer it from down to sunset
and in pleasure hurry glass after glass
Of the old wine that to dream invites
Shall you find it hidden in their sediments
my friends, its bitterness do not course
for it’s been its yeast exquisiteness
The essence of my blood and of my life

The sediments of wine - Omar Khayyam, Persian, 10th century

A compound present in red wine would avoid a series of health problems related with aging, since it benefits the heart and strengthens the bones, in addition to prevent cataract formation, reported researchers on Thursday.

In this research project, scientists studied mice fed a standard diet but with an additional Resveratrol complement when these mice had an approximate equivalent of the human average age. This study is the first one to generate hope that this compound, or drugs based on it, can improve people’s health.

Most of the mice that were under Resveratrol treatment did not live longer than other mice, but they were much healthier in important aspects, according to the article published in the magazine Cell Metabolism.

"The good news is that we can improve health. I believe that’s more important than to increase longevity," said David Sinclair, from the Harvard Medical School, who conducted the research together with Rafael de Cabo, from the US government’s National institute on Aging.

"Scientists found that mice fed a high calorie diet with a Resveratrol dose Had maximum lifespan when compared to mice on the same diet without Resveratrol," reported the authors.

"Resveratrol ended with the negative effects of adipose (fatty) tissue," affirmed De Cabo in a telephone interview.

Resveratrol, found in large quantities in grapes and in red wine, has caused great interest among scientists and some companies.
GlaxoSmithKline paid this year 720 million American dollars to buy Sirtris Pharmaceuticals Inc, a company that produces drugs that mimic the effects of Resveratrol. Experts from Sirtris participated in this study.

Concrete Benefits

During the conduction of this research, some mice were fed a standard diet, others a high-calorie diet and others were fed every day in between.

Then the scientist started treating some of the animals with a high- or low-dose of Resveratrol when they were 12 months old, an approximate equivalent of 35 human years

Rodents treated with Resveratrol experienced several health benefits compared to untreated mice, explained the team of researchers.
Resveratrol treated mice experienced less age-related and obesity-related cardiovascular functional decline. Their total cholesterol lowered, their aortas worked better, and the compound also seemed to have moderated inflammation in the heart, reported scientists.

Treated mice also tended to have better bone health than the non-treated control group. they were also found to have reduced cataract formation as well as improvement in balance and motor coordination
The genetic expression of Resveratrol-treated mice partially mimicked the genetic expression of mice under a dietary restriction, which had previously been shown to provoke slower aging process and increase longevity in some mammals.

The study was based in a previous publication, dating from 2006, that revealed that Resveratrol improved health and longevity in overweighed mice.

De Cabo said that although the new findings are encouraging, it would be premature to recommend Resveratrol nutritional supplements for human use, since it yet remains to be studied how this compound would interact with other drugs (Source: Reuters information distributed by Yahoo)

Note of the editors of Diario del Vino: Omar Khayyam was a Perisan poet, philosopher and scientist from the 10th century. He died at the age of eighty. A great amount of his prolific activities in all the fields of knowledge was tinged by his extraordinary love for wine – which he thought of as an elixir of life- and to which he dedicated innumerable poems. Noticeably, Omar Khayyam, enlightened with the inspiration of poets and visionaries, anticipated about a thousand years to the investigations of prestige contemporary universities.

More on this topic:

Red wine improves life quality during old age
White wine with the healthy effects of the reds

July 7th, 2008



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